Superfamily analysis

C. Implications of Superfamily Analysis for Current Definitions of Enzyme Function... 

Parameterization of Semiempirical MO Methods Pharmacophore and Drug Discovery Quantitative Structure-Property Relationships (QSPR) Shape Analysis Structural Similarity Measures for Database Searching Structure and Substructure Searching Structure Databases Superfamily Analysis Understanding Protein Function from Structure and Sequence Three-dimensional Structure Searching. 

Protein Modeling Protein Structure Prediction in ID, 2D, and 3D Superfamily Analysis Understanding Protein Function from Structure and Sequence. 

SUPERFAMILY ANALYSIS UNDERSTANDING PROTEIN FUNCTION FROM STRUCTURE AND SEQUENCE 2859... 

Superfamily Analysis Understanding Protein Function from Structure and Sequence... 

Using enzymes as model systems, we begin with a discussion of the primary concepts in superfamily analysis emphasizing some recent observations about how enzyme function may relate to enzyme structure. The use of enzymes is of particular advantage in developing the theory and applications of superfamily analysis. This is because enzymes perform chemistry... 

Application of Superfamily Analysis to Individual Members of the Enolase Superfamily... 

Once the primary structure-function correlates of the well-characterized members of the enolase superfamily were elucidated, that information could be used to understand other superfamily members for which much less information was available. Two examples given below show the power of this technique for prediction of function from unknown reading frames and for extending the understanding of the function and mechanism of enzymes that have been incompletely characterized. The use of superfamily analysis for limited characterization of proteins of unknown function is also illustrated. 

Because superfamily analysis deals with very distantly related proteins, the technical issues associated with its practice are also significant. With some additional effort, useful comparisons of very distantly related sequences and structures can be accomplished using tools developed for the analysis of closer family relationships. These issues will be discussed below, along with a summary of some recently developed methods that extend the usefulness of sequence information by integrating it with available three-dimensional structure information. 

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