Sulphur- or Oxygen-bonded Compounds

Such sugar-metal complexes as (444) were formed in high yield by electrolysis of the appropriate ligand (see p. 133) in methanolic solution using anodes of the metal (Cu or Ni or Co) and a platinum cathode. The interaction between Cu cations and adenosine, guanosine, cytidine, and uridine in aqueous DMSO at various pH values has been studied by e.s.r. and n.m.r. spectroscopy. Since Cu cations were shown to complex specifically with 0-2 and 0-3 of these nucleosides at pH 8.5-10, complex formation can be used to distinguish 5 -ribonucleotides from 2 - and 3 -ribonucleotides and 2 -deoxyribonucleosides. Under certain conditions, Cu cations can form complexes having as many as four bases bound to the metal. 

Steigman, L. Hwang, and S. Srivastava, J. Labelled Compounds, Radiopharm., 1977, 13, 160 (Chem. 

---