Voriconazole Sulphonylureas

ITRACONAZOLE, FLUCONAZOLE, MICONAZOLE, VORICONAZOLE SULPHONYLUREAS t risk of hypoglycaemic episodes Inhibition of CYP2C9-mediated metabolism of these sulphonylureas Watch for and warn patients about symptoms of hypoglycaemia >- For signs and symptoms of hypoglycaemia, see Clinical Features of Some Adverse Drug Interactions, Hypoglycaemia... [Pg.568]

ANTICOAGULANTS - ORAL 5. ANTIDEPRESSANTS - mianserin, paroxetine 6. ANTIDIABETIC DRUGS - repaglinide, sulphonylureas 7. ANTIEMETICS - aprepi-tant 5-HT3-antagonists 8. ANTIFUN-GALS - fluconazole, itraconazole, ketoconazole, voriconazole 9. ANTIPSY-CHOTICS - apiprazole, chlorpromazine, haloperidol 10. BETA-BLOCKERS-metoprolol, propanolol, timolol... [Pg.288]

Miconazole and voriconazole are inhibitors of the cytochrome P450 isoenzyme CYP2C9, by which many of the sulphonylureas are metabolised. Inhibition of this isoenzyme would therefore be expected to lead to an accumulation of the sulphonylurea and therefore an increase in its ef-... [Pg.480]

The manufacturers of voriconazole advise increased blood-glucose monitoring in patients taking sulphonylureas, and until more is known this seems prudent. [Pg.481]

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