Sulfur Linker Units

Sulfur-based linker units have been developed that utilize the reactivity of sulfur in a multitude of different forms and oxidation states. i ° The simplest linker units are the thioether-based linkers, and initially conditions for traceless cleavage of aliphatic 

LINKER STRATEGIES IN MODERN SOLID-PHASE ORGANIC SYNTHESIS 

Oxidation to the sulfoxide or sulfone can also be used as a method to activate sulfur linker units. Typically, it is easier to oxidize aU the way to the sulfone, but specialized strategies have been developed that allow intermediate oxidation to the sulfoxide. Moreover, sulfoxides can be loaded onto resins directly , but it is far more common to 

By varying the cleavage cocktail, it is also possible to generate very diverse libraries of heterocyclic species upon cleavage from sulfone linkers (Table 1.11, Entries 22-25). Such work has been extensively developed by Kurih , and Ganesan ,  

---

Ciobanu and Poirier (Scheme 3.42). This synthesis made use of a multifunctional sulfamate linker unit, prepared by loading steroidal sulfamates 234 onto simple trityl chloride resin 182. After solid-phase modifications (coupling with amino acids and carboxylic acids to introduce two levels of molecular diversity), cleavage with piperazine (10 equiv) at 45°C cleaved the sulfur-oxygen bond providing the phenols... 

---