Sulfone Linkers in Oligosaccharide Synthesis

Besides heterocyclic synthesis, the sulfone linker unit has also been applied to the preparation of a variety of other substrates. The diverse cleavage strategies that can be applied to cleave substrates from sulfone linkers make them a versatile multifunctional linker. This together with the simple purification process, compared to solution-phase synthesis, adds to the potential of sulfone chemistry being applied to solid-phase synthesis. 

Seneci, Solid-Phase Synthesis and Combinatorial Technologies, Wiley, 2002, pp. 91-135 (b) J. Buchele, H. A. Mayer, Chem. Common. 1999, 2165 (c) N. Ljungdahl, K. Bromlield, N. Kann, Top. Curr. Chem. 2007, 278, 89. 

in Scott, P. J. H. (Ed.), Linker Strategies in Solid-Phase Organic Synthesis, Wiley, 2009, 591-656. 

Rappoport, C. Stirling, The Chemistry of Sulfones and Sulfoxides, Wiley, Chichester, 1988 (b) N. S. Simpkins, Sulfone in Organic Synthesis, Pergamon Press, Oxford, 1993 .(c) S. Patai, Z. Rappoport, The Synthesis of Sulfones, Sulfoxides and Cyclic Sulfides, Wiley, Chichester, 1994. 

Schwyzer, E. Felder, P. Failli, Helv. Chim. Acta. 1984, 67, 1316. 

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