Sulfonamides idiosyncratic drug reactions

The majority of adverse effects to sulfonamides are mild in nature and reversible, although idiosyncratic drug reactions may occur. Urinary tract disturbances, including sulfonamide crystalluria and hematuria, can be minimized in susceptible animals by maintaining an adequate water intake to maintain a high urine flow. Bone marrow depression and dermatologic reactions have also been associated with sulfonamide therapy in animals. 

Ghajar BM, Naranjo CA, Shear NH, Lanctot KL. Improving the accuracy of the differential diagnosis of idiosyncratic adverse drug reactions (lADRs) skin eruptions and sulfonamides. CUn Pharmacol Ther 1990 47(2) 127. 

The reaction of N-oxygenated drugs and metabolites with glutathione may also have toxicological and medicinal implications. Thus, the addition of GSH to nitrosoarenes, probably followed by rearrangement, forms sulfinamides (reaction 9), which have been postulated to contribute to the idiosyncratic toxicity of a few drugs such as sulfonamides... 

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