Sulfonamide ethoxylates

Recently, an aqueous solution of perfluoroalkyl sulfonamide ethoxylate, QF,7S02N (C3H7)(C2H40)ioH, designated as QF17EO10 having a medium chain length (Cg)... 

Celecoxib (57) and rofecoxib (58) are marketed COX-2 inhibitors. Celecoxib has a relatively poor B/P ratio of 0.1 compared to refecoxib, which has a B/P ratio of 0.8. Presumably, changing from the sulfonamide to the methyl sulfone removes a hydrogen bond donor and allows for belter brain penetration. Keeping the methyl sulfone intact, a new pyrazolo[l,5-b]pyradazine COX-2 inhibitor (59) has been developed which shows an enhanced B/P ratio of 1.5. The ethoxyl and new pyrazolo[l,5-b]pyradazine moieties help lower logP and allow for better brain penetration. 

More than 115 molecular stractures were found in international industrial blends of food packaging (paper and board). They belong to the groups of mono-PFAPs, di-PFAPs, S-diPAPs, polyfluoroalkyl-ethoxylates, polyfluoroalkyl-acrylates, polyflu-oroalkyl-amino acids, polyfluoroalkyl-sulfonamide phosphates, and thioacids, some... 

April 5, 1972 (Cl. 430/343 430/524 430/531 430/538). Appl. 99,512, December 18, 1970, 15 pp. Improved photosensitive compositions comprising A. an acid salt of a leuco aminotriarylmethane such as tris(4-N,N-diethylamino-o-tolyl)methane B. a hexaarylbiimidazole such as a 2,2 -bis(o-chloro-phenyl)-4,4 5,5 -tetraphenylbiimidazole and C. a redox couple containing (1) as an oxidant a polynuclear quinone absorbing principally in the 400-550 nm region such as 1,6-pyrenequinone, and (2) as a reductant an acyl ester of triethanolamine such as triethanolamine triacetate optionally mixed with a lower alkyl ester of a nitrilotrialkanoic acid such as 3,3, 3"-nitrilotripropionic acid, trimethyl ester are effective color forming compositions useful in a variety of applications. The need for an effective plasticizer system was solved by the addition of sulfonamides and ethoxylated phenol derivatives. 

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