Sulfamylon - Mafenide acetate

Sulfamylon for 5% topical solution is provided in packets containing 50 g of sterile mafenide acetate to be reconstituted in 1000 mL of sterile water for irrigation or 0.9% sodium chloride irrigation. After mixing, the solution con-... 

Bum wounds— anti-infective Mafenide acetate Sulfamylon... 

The client with a partial-thickness burn to the right arm is prescribed mafenide acetate (Sulfamylon), a topical antimicrobial. Which intervention should the emergency department nurse implement when applying this medication ... 

Mafenide (sulfamylon), as hydrochloride and acetate is extensively used in treatment of bums, and has significantly lowered the mortality from bum wound sepsis (YAFEE and Dressler 1969). It was found to be a common sensitizer in studies performed in Munich, outnumbered only by benzocaine in the years from 1960 to 1965 (Bandmann 1966). Mafenide acetate must not be used in patch testing, because patients sensitized to mafenide hydrochloride do not react to mafenide acetate (ScHREUS 1950). Cross-reactions to other related esters ofp-aminobenzoic acid occur relatively often (Bandmann 1967 Schulz 1962). Sulfonamides do not cross react with mafenide. Bandmann and Breit (1973) have reviewed the mafenide story. 

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