Sugars, conjugation with

During this period, Laurie also investigated the preparation of radiolabeled, iodo and bromo sugars via carbohydrate boranes (with J.-R. Neeser), fluorescent probe-sugar conjugates (with M. Yalpani), sugar ferrocene derivatives (with M. J. Adam), and extended his studies of the conformations of polycyclic sugar derivatives. 

Many peptide antibiotics have novel structural motifs, such as cyclic structures and are often further modified, (such as in jS-lactamic antibiotics) and conjugated with sugars, lipids, and other molecules. 

The introduction of Py at the 2 sugar position of uridine and Ptz at the 5 -end of ODN caused an increase in Tm. The Tm for PtzPy-1 is 39.4 °C, which is 6.9 °C higher than that of unmodified ODN (32.5 °C). Similarly, the introduction of Ptz or Py into ODN showed increases in Tm for Ptz-1 (1.2 °C) and for Py-1 (6.6 °C) compared with unmodified ODN, suggesting that Py intercalated into ODN duplex at the 3 -side, and the 5 -linked-Ptz associated with the 5 -terminus by end-capping [5]. The structures of ODNs conjugated with Py and Ptz were examined by circular dichroism (CD) spectral measurements. The CD spectra of ODNs in 20 mM phosphate buffer were characteristic of the B-form. 

This review deals with the synthesis of porphyrinyl-type sugar conjugates developed and biologically accessed, and considers the involvement of macrocycles of the porphyrin and chlorin (dihydroporphyrin) types, with O- and 5-glycosides or ether and ester functions. 

The highly basic BPI molecule is envisaged to interact initially with the charged surface sites (i.e. the charged sugar conjugates or phosphate... 

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