Sufentanil Vecuronium

Clinically significant bradycardia or asystole occurred on induction when sufentanil was used in conjunction with vecuronium (17,18). 

Starr NJ, Sethna DH, Estafanous FG. Bradycardia and asystole following the rapid administration of sufentanil with vecuronium. Anesthesiology 1986 64(4) 521-3. 

Dobson JAR, Davies JM, Hodgson GH. Bradycardia after sufentanil and vecuronium. Can J Anaesth 1988 35 S121. 

The expected cardiovascular stability of vecuronium has been confirmed in man (2,21-23). Even doses as large as 0.28 mg/kg in patients undergoing coronary artery bypass grafting produced negligible effects (24). Bradycardia is the only cardiovascular adverse effect reported, and this is seen in association with opioids such as fentanyl (25) and sufentanil (SEDA-11, 125) (26) or other drugs that are themselves capable of producing bradycardia. The lack of vagolytic and sympathomimetic activity of vecuronium... 

Noninterfering alfentanil, aprotinin, atropine, bupivacaine, chlorpromazine, dalteparin, dexamethasone, diazepam, dopamine, droperidol, etomidate, fentanyl, furosemide, gallamine, haloperidol, midazolam, morphine, neostigmine, nitroglycerin, nitroprusside, oxytocin, pancuronium, pentobarbital, phenylephrine, phenytoin, pipecuronium, piperacillin, promethazine, propofol, ranitidine, succinylcholine, sufentanil, terbutaline, thiopental, vecuronium, verapamil... 

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