Sucralfate Tricyclic antidepressants

Clinically important, potentially hazardous interactions with amiodarone, antacids, arsenic, bepridil, bismuth, bretylium, didanosine, disopyramide, erythromycin, NSAIDs, phenothiazines, procainamide, quinidine, sotalol, sucralfate, tricyclic antidepressants, zinc salts... 

Drugs that may affect ketoconazole include antacids, didanosine, histamine H2 antagonists, isoniazid, sucralfate, proton pump inhibitors, and rifampin. Drugs that may be affected by ketoconazole include oral anticoagulants, corticosteroids, cyclosporine, protease inhibitors, tricyclic antidepressants, carbamazepine. 

When 6 healthy subjects took a single 75-mg dose of amitriptyline with a single 1-g dose of sucralfate, the AUC of the amitriptyline was reduced by 50%. Concurrent use should be monitored to confirm that the therapeutic effects of the antidepressant are not lost. An increase in the dosage may be needed. There seems to be nothing documented about other tricyclics. 

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