Succinyl azide

Diazide of carbonic acid (V) is exceptionally sensitive to friction it explodes on contact with a glass rod (Curtius and Heidenreich [149]) Succinyl azide [150] and other acyl azides [151] behave similarly. 

Succinyl azide is obtained readily from the acid chloride and sodium azide. The preparation of the hydrazide from the ester is complicated by the formation of small amounts of the cyclic secondary hydrazide (V) this side reaction can be avoided, however, by the choice of the proper reaction conditions. 

The above directions are based upon the methods of Hoogewerff and Van Doip, as modified by Holm and by Hale and Honan. -Alanine has also been prepared by the action of h3q)obromite upon succinimide and hydrolysis of the resulting /3-ureidopropionic acid by the action of ammonia upon /3-iodo-propionic acid by the hydrolysis of methyl carbomethoxy-/8-aminopropionate, obtained by the action of sodiiun methoxide on succinbromimide by the reduction of 3-nitrosopropionic acid by heating ethyl acrylate with alcoholic ammonia from succinyl-glycine ester by the azide synthesis and by the action of liquid ammonia upon methyl acrylate. ... 

Umlagerung von Methylmalonyl-CoA in Succinyl-CoA. HI. Reinigung und Eigenschaften der Methylmalonyl-CoA Isomerase. Biochem J 336 77-98 Owais WM and Kleinhofs A (1988) Metabolic activation of the mutagen azide in biological systems. MutatRes 197 313-323... 

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