Succinimidyl group

The very effective ir-stacking interactions between aromatic molecules and the graphitic sidewalls of SWCNTs were demonstrated by the aggregation of the bifunctional N-succinimidyl-l-pyrenebutanoate [196], irreversibly adsorbed on the hydrophobic surfaces of the SWNT. With these conjugates, the succinimidyl group was nucleophilically substituted with amino groups from proteins such as ferritin or streptavidin (Fig. 1.14) and caused immobilization of the biopolymers at the tube surfaces [196],... 

Diaryl carbonates (e. g. carbonyl diimidazol, 4-nitrophenyl carbonate) can react sequentially with carbohydrate derivatives to furnish mixed sugar carbonates (O Scheme 81f) [456]. Although normally anomeric mixtures are generated the use of a succinimidyl group, in the presence of K2CO3, was effective for the synthesis of pure 8-carbonates. 

The aldehyde groups in acetal-PEG, which is a modifier of CS, enable binding to the amino groups present on the CS backbone. Acetal-PEG-fo-PLA can serve as a micelle-forming polymer to create aldehyde-terminated polymeric micelles, which act as crosslinkers. These micelles and DS-PEG were then used as crosslinkers due to the fact that both aldehyde groups on the surface of the polymeric micelle and the succinimidyl groups at the termini of DS-PEG can bind with the amino groups of the backbone chain of CS. 

The electrografted polymeric films can be loaded with different substances allowing the development of new composite materials." To obtain modified surfaces with specific properties, more complex polymers have been electrografted. For instance, an acrylate with a IV-succinimidyl group, highly reactive with nucleophiles, has been substituted by a ferrocene group or even by biotin-avidine... 

CF3COO-succinimidyl, CH2CI2, 0°, 85% yield.These conditions selectively introduced the TFA group onto a primary amine in the presence of a secondary amine. 

For functionalization of S-layer-coated liposomes, the S-layer lattice was stabilized by cross-linking the S-layer subunits with either periodate-oxidized raffinose or bis(sulfo-succinimidyl) suberate (BS ). Both are amine group-specific reagents that were large and... 

Tian and co-workers [148] have reported the synthesis of two chlorinated fluoresceins probes 4,7,2,7 -tetrachloro-6-(5-carboxypentyl) fluorescein and 4,7,4,5 -tetrachloro-6-(5-carboxypentyl) fluorescein for labeling proteins. More recently, the same research group has described the synthesis of two novel chlorinated fluoresceins, namely 2,4, 5, 7 -tetrachloro-6-(5-carboxypentyl)-4,7-dichloro fluorescein succinimidyl ester 52 and 2, 4, 5, 7-tetrachloro-6-(3-carboxypropyl)-4,7-dichlorofluorescein succinimidyl ester 53 [149]. 

Figure 4.11 DSC can react with hydroxyl groups to create a succinimidyl carbonate intermediate that is highly reactive toward nucleophiles. In the presence of an amine-containing molecule, the active species can form stable carbamate linkages.

SIAX, succinimidyl-6-((iodoacetyl)amino)hexanoate, is a heterobifunctional reagent containing an NHS ester on one end and an iodoacetyl group on the other end (Brinkley, 1992)... 

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