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Substrate Scope, Activity, and Enantioselectivity

HNLs often exhibit only low activity toward industrially relevant compounds. Thus, a lot of effort was (and still is) made to engineer HNLs for the acceptance of unfavorable substrates by rational design and directed evolution. [Pg.612]

TABLE 25.2 Summary of Engineered HNL Variants Exhibiting Improved Properties  [Pg.613]

PaHNL5 LlQ/AlllG Improved yield and ee in the synthesis of (R)-2-chloromandelonitrile [37] [Pg.613]


See other pages where Substrate Scope, Activity, and Enantioselectivity is mentioned: [Pg.612]    [Pg.616]   


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And enantioselectivity

Enantioselective activation

Enantioselectivity substrate

Substrate Scope

Substrate activation

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