Substantia nigra reticulata subthalamic

Robledo P, Feger J (1990) Excitatory influence of rat subthalamic nucleus to substantia nigra pars reticulata and the pallidal complex electrophysiological data. Brain Res 578 47-54. 

Fig. 1. Distribution of CBi and VRl receptors in the basal ganglia circuitry in rats. CPU, caudate-putamen GP, globus pallidus STN, subthalamic nucleus SWpr, substantia nigra pars reticulata SWpc, substantia nigra pars compacta...

Nakanishi H, Kita H, Kitai ST (1987b) Intracellular study of rat substantia nigra pars reticulata neurons in an in vitro slice preparation electrical membrane properties and response characteristics to subthalamic stimulation. Brain Res., 437, 45-55. 

Lesions in different anatomical sites of the structures that make up the motor loop can be used to create models of movement disorders (Fig. 1). When the subthalamic nucleus is lesioned, a disruption of the indirect pathway results the decline of glutamatergic stimulation of internal globus pallidus/substantia nigra zona reticulata (SNR) neurons via subthalamico-pallidonigral pathways reveals diminished inhibition of the excitatory thalamocortical pathways. The clinical consequence of this lesion is a proximal ballistic movement of the limbs. 

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