Subject technetium

The majority of cluster technetium compounds are subject to thermal decomposition topochemically (i.e. their decomposition reaction occurs in the solid phase), [H(H20)2]2 [Tc8Br4( -Br)8]Br2 being an exception. This compound melts before decomposition (at 610-620 °C), which is good evidence in favour of the molecular crystalline structure of its dehydrated form [Tc8Br4(/i-Br)8]Br2. ... 

Chan, H-K., Daviskas, E., Eberl, S., Robinson, M., Bautovich, G., and Young, I.H., Deposition of aqueous aerosol of technetium-99m diethylenetriamine pentaacetic acid generated and delivered by a novel system (AERx) in healthy subjects, Eur. J. Nucl. Med., 26 320-327 (1999). 

TABLE IV. Retention of 99m-technetium-labeled formulations in the nasal cavity in human subjects (n = 6)... 

The most common methods are and electrolytic reduction. The presence of impurities causes the main difficulties in the preparation of proteins labeled with technetium. Thus the quality control and the assay of product contamination with tin colloid is the subject of several papers Cifka studied the conta-... 

Attenuation of the 78-keV photons recorded when thalium is employed in studies on human subjects makes the diagnosis of diseases in women difficult because of the overlying breast. The technetium-labelled agents do not show these limitations. 

Introduction.—The organometallic chemistry of technetium and rhenium reported during 1974 has been surveyed. The ligand-induced redox reactions of rhenium halides have been reviewed, and the chemistry of cyanide complexes of Group Vila metals has received attention. The electrochemistry of technetium and rhenium has been the subject of two reviews, and a general monograph on the production, uses, and disposal of technetium has appeared. Recently published crystal structures of complexes of technetium and rhenium have been collated. ... 

Uchida T, Nemoto T, Yui T et al (1979) Use of technetium-99m as a radioactive label to study migratory patterns of leukocytes. J Nucl Med 20 1197-2000 Vallabhajosula S, Machac J, Goldsmith SJ et al (1986) Indium platelet kinetics in normal human subjects tropolone versus oxine methods. J Nucl Med 27 1669-1674... 

Introduction—The organometallic chemistry of technetium and rhenium has been the subject of three reviews. Interesting new developments in the chemistry of these elements reported this year include the first preparation and characterization of ReOCl2 which, compared with the other oxochlorides of rhenium, is relatively stable with respect to reaction with air or water, it is however markedly thermally unstable. Re03l has been observed by mass spectrometry in the vapour from a mixture containing Re03 and... 

While widely used, this procedure is subject to several difficulties and limitations, (a) It allows introduction of only one type of ligand, or one distribution of ligands, into the technetium radiopharmaceuticaL (b) It does not allow specific control over the final oxidation state, coordination number, coordination geometry, etc. of the technetium in the Tc-L product, (c) The reductant, especially Sn, is often incorporated into the final product (1,6). (d) The excess reductant is injected into the patient tindl) has a long biological half-life (7) and causes several deleterious side effects (8). 

---