Subject from succinimides

Allylsilane 59 was obtained by initial reaction of the succinimide 55 with the corresponding Grig-nard alkylsilane and a subsequent simple sequence of reactions. This allylsilane was readily cyclized in formic acid at room temperature to 60, which was subjected to a Wacker oxidation (Tsuji 1984) to afford the dihydroanatoxin-a derivative 28. The nitrogen deprotection step with iodotrimethylsilane (Melching et al. 1986) funushedthe ( )-dihydroanatoxin-a, which was reprotected with oc according to the previously discussed Rapoport methodology (Sardina et al. 1989) to furnish the racemic ( )-anatoxin-a. The overall yield of this synthesis was 7% from the succinimide. 

There has been a slight increase in activity in this area compared with that in the previous two year period. For the polymeric esters of acrylic, methacrylic acids, and related polymers the simplest reaction, apart from thermal depolymerization, is hydrolysis, and one or two papers on this subject have appeared. One of these concerns a comparison of the kinetics of hydrolysis of a number of methacrylate esters and a further two deal with the formation of copolymers containing carboxylic acid functions. Methyl trifluoroacrylate forms alternating copolymers with cE-olefins (ethylene, propylene, isobutylene) and these are readily hydrolysed in boiling aqueous methanolic sodium hydroxide to yield hydrophilic fluoropolymers. Hydrolysis is reported to be nearly quantitative with no chain scission. An alternating copolymer is also formed by radical polymerization of maleic anhydride with A-vinyl succinimide. On hydrolysis this copolymer is... 

---