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Structure-Specific Recombination at Transcribed S Regions

Bloom s syndrome, the genetic disease resulting from deficiency in BLM helicase, is characterized by a predisposition to malignancy and also immunodeficiency. In individuals affected with Bloom s syndrome, production of immunoglobulin-producing plasma cells and class switch recombination is impaired.BLM helicase actively unwinds G4 Deficient unwinding [Pg.242]

2 MutSd Targets G4 DNA in G-loops to Promote S Region Synapsis [Pg.242]


See other pages where Structure-Specific Recombination at Transcribed S Regions is mentioned: [Pg.241]   


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Recombination structures

S , structure

Specific structure

Structural region

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