Structure-growth inhibitory activity relationship

Keskin O, Bahar I, Jernigan RL et al. Characterization of anti-cancer agents by their growth inhibitory activity and relationships to mechanism of action and structure. Anti-Cancer Drug Design 2000 15 79-98. 

Information on the structure-activity relationships of enantiomers of ipconazole as well as their fungicidal and plant growth inhibitory activities has been published by Saishoji et al. [72] and Ito et al. [73]. QSARs and three-dimensional shape studies of fungicidal azoylmethyl-cyclopentanols such as ipconazole and metconazole are available from Ref [70]. 

The 45 members of the cephalostatin/ritterazine family isolated to date, together with a growing number of analogues and related monosteroidal antineoplastics provide the basis for elueidating some structure -activity relationships (SAR) of these potent cytotoxins and for diseovering the minimum pharmacophore required to maintain potent cancer cell growth inhibitory behavior. 

Mcllwain (240) has used the structural relationship between iodinin and the antagonistic quinones as a model for preparing quinoxaline di-i -oxides related to compounds of anti-hemorrhagic activity. The di-iV-oxides were inhibitory to bacterial growth, the parent diazines were inactive. These inhibitors were less active than iodinin. 

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