Structure and Analysis of Nucleosides

The structures of the dialdehydes obtained by periodate oxidation of adenine nucleosides have been investigated no free aldehyde was detected, and the major form present in crystalline products was thought to be the di-hemi-acetal hydrate 

The conformation of nucleosides and nucleotides has been reviewed.The conformation of 2-alkylthio-2, 3 -0-isopropylidene-adenosine derivatives has been studied by i.r. and c.d. measurements a strong hydrogen bond exists between N-i and 0-5 in carbon tetrachloride, indicating a syn conformation for the base c.d. curves, which are markedly dependent on the sulphur substituent, suggest a syn conformation in chloroform and an anti arrangement in water. 

evidence, confirmed by an X-ray crystal structure study, indicates that 9-/3-D-arabinofuranosyl-8-n-butylaminoadenine adopts the a ft-conformation in 

Davies, Progress in Nuclear Magnetic Resonance Spectroscopy , Vol. 12, Pt. 3, Pergamon, Oxford, 1979. 

Higuchi and K. Nucleic Acids Res. Symp. 6th, Spec. Publ., 1978, 5, 367 

A statistical survey of crystal structures of nucleic acid constituents has led to the proposal that a full description of nucleoside molecular geometry can be given in terms of four parameters the phase angle of pseudorotation, P, the puckering amplitude, the conformation of the side-chain, 5, and the glycosidic torsional angle, X these allow the variability of bond and torsion angles to be described.  

Theoretical calculations of H n.m.r. J values have been made to assist conformational analysis of isomeric pentofuranosyl nucleosides the results for cisoid hydrogens were used to calculate the conformation of o-xylo-, j3-lyxo-. 

The conformation of 5 -deoxy-5 -adenosine acetic acid (69) regarded as a model for 5 -AMP, has been established by X-ray crystal-structure analysis. 

Soedin., 1980, 578 Chem. Abstr., 1980, 93,186 722)..  

The influence of metal ions on the Raman and n.m.r. spectra of several nucleosides in DMSO has been investigated, and literature data on ion-nucleoside interactions in this solvent are also summarized. 

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