Structure-activity relationships chemical arrays

The wide array of 16-membered macrolides has amply supplied chemists with starting materials for structural modifications, and the extensive structural variations have provided a wealth of ideas from which hybrid molecules have been conceived. In addition to synthesis by purely chemical means, structural modifications have been effected by bioconversions, alterations of biosynthetic pathways, and genetic manipulations of macrolide-producing micro-organisms [13]. These natural structural variations have also contributed to a better understanding of structure-activity relationships and have been used to successfully guide synthetic programmes. Finally, these complex natural products have inspired numerous... 

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