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Structural-Based Mechanisms of SERM Estrogen-Like Action

Structural-Based Mechanisms of SERM Estrogen-Like Action [Pg.145]

Although much progress has been made in our understanding of estrogen and antiestrogen action, there is no unifying theory that has explained the target [Pg.145]

Chambon s group [40] was the first to address the issue of the target site estrogenlike spedfidty of 4-OH-tamoxifen using recombinant human ER. They reported [Pg.146]

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Actions of SERMs

Estrogen SERMs

Estrogen mechanism

Estrogen structure

Estrogen-like actions

Mechanical structure

SERM mechanism

Structural mechanic

Structural mechanism

Structure Action