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Structural Aspects of Kinases and Their Inhibitors

The first section describes the structure of kinases in general, the specific domains as well as the activation mechanism, and is followed by a section on the different kinase inhibition principles. In the next section, a detailed description of the structural features of all kinase inhibitors currently cocrystallized with their target kinase is given. Finally, some structural features that determine the selectivity of several kinase inhibitors are addressed. [Pg.191]

The aim of this review is to give the reader a brief overview of the exciting research field of protein kinases. It is, however, by no means a comprehensive overview, and I would like to invite motivated readers to read one of the many excellent reviews on this research topic [4], [Pg.191]

Tarceva (Erlotinib, OSI-774) OSI/Roche/Genentech, EGFr Phase III [Pg.192]

Status Company Drug Disease Kinase target [Pg.193]

Launched Novartis Gleevec (STI-571, Imantinib) Cancer Abl (cKit, PDGF) [Pg.193]

See other pages where Structural Aspects of Kinases and Their Inhibitors is mentioned: [Pg.191]    [Pg.192]    [Pg.194]    [Pg.196]    [Pg.198]    [Pg.200]    [Pg.202]    [Pg.204]    [Pg.206]    [Pg.208]    [Pg.210]    [Pg.212]    [Pg.214]    [Pg.216]    [Pg.218]    [Pg.191]    [Pg.192]    [Pg.194]    [Pg.196]    [Pg.198]    [Pg.200]    [Pg.202]    [Pg.204]    [Pg.206]    [Pg.208]    [Pg.210]    [Pg.212]    [Pg.214]    [Pg.216]    [Pg.218]    [Pg.204]    [Pg.244]    [Pg.918]    [Pg.272]    [Pg.144]    [Pg.7]    [Pg.239]   


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