Antipsychotic structural analogs

Drug discrimination has also been used to compare antipsychotic drugs that act through different receptor mechanisms. The close structural analogs olanzapine and quetiapine... 

SAR Terfenadine was discovered in the course of an extensive and intensive search for new butyrophenone antipsychotic drugs as could be seen by the presence of the N-phenylbutanol substituent. It is also studded with a diphenylmethyl piperidine group structural analogous as is normally observed in the piperazine antihistaminies. 

Figure 9.2 Structural analogs of classical bioisosteric replacement of antipsychotic drugs.

To search for novel neuroleptic agents, attention has been given to structural modifications of dibenzoepines such as clozapine (9) [ 17] as a clinically active atypical antipsychotic, and its analogous fluperlapine (10) [18, 19] with a pharmacological resemblance to clozapine. Some 2-piperazinyl-5-phenyl-... 

Finally, this reaction motif has been used in the synthesis of analogs of the antipsychotic sertindole for structure-activity relationship (SAR) studies [19]. Specifically, the substitution was effected at the 5-position of the indole nucleus to give analog 21. 

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