Strophanthidin 3-acetate

Gibberellic acid and (2,4-dichlorophenoxy) acetic acid increased the glycoside content of Omithogalum umbellatum, as measured by a biological assay of extracts. The active principle, strophanthidin, is one of the cardiac glycosides. 7 There is little reference in the literature to this type of work, but the hydrolytic effects of gibberellic acid on starch may shift the equilibrium toward phenyl glycoside formation in some plant species. 

Reduction of at,p-oxidoketones. In a study of potential routes to the A/B ring system of cardiac-active steroids (periplogenin, strophanthidin), Robinson and Henderson studied the reduction of 4/ ,5/ -oxidocholestane-3-onc (1) with chromous acetate. The best results were obtained by reduction of (I) with a large excess of freshly... 

Alternately, the hydrochloric acid solution from the removal of the strophanthidin may be buffered with sodium acetate until it is no longer acid to Congo Red. The solution is then concentrated to dryness under reduced pressure at a temperature not exceeding 35° and the residue thoroughly extracted with hot ether. Further purification proceeds as above. 

Strophanthidinic acid methyl ester 3-acetate (CCXXXV) 10X 10-6 320... 

---