Stroke, cause pathophysiological

Ischaemic stroke is the third leading cause of death in industrialized countries. The debilitating or lethal consequences of transient or temporary reductions in cerebral blood flow are not only caused by necrosis in the infarct zone itself, but also by pathophysiological events in the peri-infarct zone [14]. Apparently, the release of inflammatory mediators such as cytokines and NO contributes to tissue inflammatory injury. There is also evidence for apoptosis in the peri-infarct zone. These processes offer novel targets for therapeutic strategies. In this respect, the potential of neurotrophic factor treatment is described in Section 2.4.2.6. 

Epidemiology, risk factors, pathophysiology and causes of transient ischemic attacks and stroke Epidemiology... 

Stroke is a leading killer worldwide and the third leading cause of death in the United States, behind cardiovascular disease and all cancers. Despite improvements in the stroke mortahty rates in the second half of the twentieth century, stroke occurs in more than 700,000 individuals per year and results in 150,000 deaths. Recent advances in our knowledge of the pathophysiology of stroke have led to evidence-based recommendations on the management of the stroke patient. 

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