String synthesis

Any combinatorial synthetic method carried out with macroscopic solid support units, even if coding is omitted, has to ensure that the route of every unit in the entire multistep synthetic process can be traced. In string synthesis this can be achieved by... 

There are different possibilities for practical realization of the principles and the string synthesis described below represents only one of them. 

The support units used in the string synthesis were Chiron Mimotopes Crowns shown in Fig. 1. They were used together with different color stems, also purchased from Chiron Mimotopes. Spatially ordered groups are formed with the crowns (Fig. 1A) by stringing them together with a thread. The stems serve to string the crowns together and to facilitate redistribution. The stems were modified as shown in Fig. 1. 

The software for the string synthesis technique is written in visual basic and the data appear in Microsoft Excel sheets. This software can be downloaded via the Internet from http //szerves.chem.elte.hu/furka by clicking on the title ExcelBook appearing on the lower part of the main page. This software is compatible with only those PC systems that have Excel installed. 

In this case, the products formed in the support units can be identified by computer prediction, based on the relative positions of the units occupied in the final groups. There are different possibilities for practical realization of the principles. In the string synthesis described below, the relative spatial arrangement of the units is maintained by stringing them. 

A Furka, JW Christensen, E Healy, HR Tanner, H Saneii. The string synthesis. A spatially addressable split procedure. J. Comb. Chem. 2 220-223, 2000. 

Plucked.cpp Program with TCL/TK GUI for plucked string synthesis. Mandolin.cpp Program with TCL/TK GUI for mandolin synthesis. 

Bowed.cpp Program with TCL/TK GUI for bowed-string synthesis. 

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