Stress hyperuricemia

Lead-induced hyperuricemia may contribute to chronic lead nephropathy. Uric acid per se induces endothelial cell injury, renal microvascular disease, and hypertension, at least in part mediated by oxidative stress [38]. Independent of uric acid, reactive oxygen species induced by lead have been imphcated in endothelial cell injury, increased vascular reactivity, and the production of hypertension in humans and experimental animals [39]. 

Here is a short but most fascinating look at the history of evolution With the stepwise loss of the enzyme uricase the quantity of uric acid increases along with further development. Very low uric acid quantities are found in lower mammals, for example porpoises (other values are 0.2 mg% in lemurs, 1,0 mg% in monkeys, and 2 mg% in anthropoids). Hyperuricemia depends on genetic factors, age, diet, alcohol, psychological and physical overload, stress, diseases (for example, polycythemia, ketose), and drugs (for example, thiacides). 

PROBLEM OF HYPERURICEMIA IN PHYSIOLOGICAL STRESS CONDITIONS This difference is statistically highly significant (p < 0.0%). 

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