Streptomycin antibacterial spectrum

Since the discovery of streptomycin in 1944, aminoglycosides have endured as indispensable agents in the antimicrobial armamentarium. This is despite their well described potential for serious nephrotoxicity and otoxicity and the emergence of other classes of antibiotics with similar antibacterial spectrums. The major aminoglycoside antibiotics in... 

C2iH4iN70,2 583.595 Aminoglycoside antibiotic. Isol. from Streptomyces humidus and obt. by redn. of streptomycin. Broad-spectrum antibacterial agent, restricted to veterinary use due to likely ototoxicity. Sol. H2O poorly sol. butanol, hexane. Log P -7.25 (uncertain value) (calc). 

Streptomycin possesses a broad spectrum of antibacterial activity. It is the first clinically effective drug used for treating tuberculosis. Synonyms of this drug are streptan, strepto-col, and others. 

---