Streptomyces hygroscopicus var geldanus

Streptomyces hygroscopicus var. geldanus and shows antibiotic activity against protozoa [206]. From the same Streptomyces strain, AM-3672, herbimycin A (124) [207], B (125) [208] and C (126) have been isolated [209]. They exhibit herbicidal and antiviral activity and are able to reverse the characteristics of oncogene expression [120]. Herbimycin A (124) has been shown to have a potent antiangiogenic activity [211]. This latter biological activity distinguishes the benzoquinoid ansamycins from their benzenoid [212] and naphthoquinoid [213] ansamycin relatives. [Pg.437]

As described above, the first benzenoid ansa macrolides were isolated from a higher plant. On the other hand, the first ansa macrolide from a microorganism was isolated from the culture filtrate of Streptomyces hygroscopicus var. geldanus and named as geldanamycin (85) [137]. Geldanamycin (85) showed an inhibitory effect on the growth and multiplication of protozoa and possessed potent cytocidal activities in vitro. [Pg.72]

Geldanamycin Streptomyces hygroscopicus var. geldanus var. nova Maytansine Maytenus ovatus Loes... [Pg.235]

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