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Streptomyces griseochromogene

There are two commercial fungicides, the antibiotics blasticidin S and kasugamycin, that act via the inhibition of protein biosynthesis (Figure 4.19). Blasticidin S is a fermentation product obtained from cultures of Streptomyces griseochromogenes, and has specific activity in the control of P. oryzae, similar to kasugamycin, a secondary metabolite of S. kasugaensis. However, much of the earlier work on mode of action was carried out using another antibiotic, cycloheximide. [Pg.96]

Blasticidin S. Blasticidin S is the first successful agricultural antibiotic developed in Japan. It was isolated from the culture filtrates of Streptomyces griseochromogenes by Takeuchi et al. (7), and the potent curative effect of blasticidin S on rice blast was found by Misato et al. (8) Thereafter the benzyl-aminobenzene sulfonate of blasticidin S was reported to be least phytotoxic to the host plant without reducing antifungal activity against Pyricularia oryzae, the pathogen of rice blast (9), and... [Pg.171]

Blasticidin S is an antibiotic of pyrimidine type, discovered in 19SS in the metabolites of Streptomyces griseochromogenes Fu i imgpetal., 1955). Blastiddin S, soluble in water, appears in the form of white needles. Its structure was eluddated by Yonehara and Otake (1966) S-[4-[3-amino-5-[(amino-imino-mcthyl)-methyl-amino]-1 -oxopentylj-amino]-1 -[4-amino-2-oxo-1 (2H)-pyrimidinyl]-1,2,3,4-tetrade-oxy- -D-er/7rohex-2-ene pyranuronic acid (9). [Pg.474]

Blasticidin S (327) is an antifungal agent used against rice blast disease in Japan. It was isolated in 1958 from Streptomyces griseochromogenes [411] and the structure and absolute stereochemistry were elucidated by chemical means [412-415] and confirmed by X-ray spectroscopy [416,417]. The biosynthesis has also been determined [418,419]. [Pg.266]

C15H24, Mr 204.36, oil, a sesquiterpene hydrocarbon of the triquinane type from cultures of Streptomyces griseochromogenes and S. UC 5319. It is the first isolable biosynthetic intermediate in the pathway from farnesyl pyrophosphate to the antibiotically active pentalenolactones. ... [Pg.472]

The final stages in the biosynthesis of the peptidyl-nucleoside antifungal agent blasticidin S, produced by Streptomyces griseochromogenes, have been eluci-... [Pg.269]

Blasticidins pyrimidine antibiotics synthesized by Streptomyces griseochromogenes (see Nucleoside antibiotics). They inhibit the growth of fungi, e.g. the rice fungus, Piricularia oryzae, and a few bacteria. The antibiotic effect is due to suppression of polypeptide chain elongation during protein biosynthesis. [Pg.74]

Blasticidin S Streptomyces griseochromogenes Cytosine 4-Deoxy-4-amino-2,3-hexen-uronic acid Cytidine, Aqrl-tRNA... [Pg.460]

Tautomycetin Immunosuppressive TauI/TmcR Streptomyces griseochromogenes C5 tautomycetin oxygenation [155,803]... [Pg.281]

C16H24N8O5 408.416 From Streptomyces griseochromogenes IF013413. Active against rice blast. Sol. [Pg.207]

C17H25FN8O5 440.433 Prod, by Streptomyces griseochromogenes IF013413 in presence of fluorocytosine. Antimicrobial agent. Powder. Sol. H2O poorly sol. butanol, hexane. [Pg.208]

C9H13N3O3 211.22 From Streptomyces griseochromogenes. Shows antitumour props. Sol. H2O. [Pg.812]


See other pages where Streptomyces griseochromogene is mentioned: [Pg.147]    [Pg.240]    [Pg.262]    [Pg.147]    [Pg.66]    [Pg.98]    [Pg.147]    [Pg.10]    [Pg.1062]    [Pg.222]    [Pg.270]    [Pg.201]    [Pg.237]    [Pg.98]    [Pg.704]    [Pg.207]    [Pg.812]    [Pg.353]    [Pg.1062]    [Pg.980]   
See also in sourсe #XX -- [ Pg.4 , Pg.18 , Pg.28 , Pg.127 , Pg.242 , Pg.269 ]




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Griseochromogenes

Streptomyces griseochromogenes

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