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Streptomyces globisporus

Liu, W. and Shen, B. (2000) Genes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027 apoprotein. Antimicrobial Agents and Chemotherapy, 44, 382. [Pg.258]

Murrell JM, Liu W, Shen B (2004) Biochemical characterization of the SgcAl a-D-gluco-pyranosyl-l-phosphate thymidylyltransferase from the enediyne antitumor antibiotic C-1027 biosynthetic pathway and overexpression of sgcAl in Streptomyces globisporus to improve C-1027 production. J Nat Prod 67 206-213... [Pg.139]

The chromoproteine antibiotic C-1027 [108] from Streptomyces globisporus has antitumor activity, unfortunately correlated with strong cytotoxicity that hampers the use of this lead structure class as a drug which is a general problem in cancer drug development (Scheme 1.5.10). The labile chromophor 61 (C-1027-Chr) con-... [Pg.75]

Jizba J, Sedmera P, Zima J, Beran M, Blumauerova M, Kan-dybin NV, Samoukina GV. Macrotetrolide antibiotics produced by Streptomyces globisporus. Folia Microbiol. (Praha). 1991 36(5) 437- 3. [Pg.951]

See other pages where Streptomyces globisporus is mentioned: [Pg.247]    [Pg.232]    [Pg.385]    [Pg.67]    [Pg.104]    [Pg.25]    [Pg.184]    [Pg.2568]    [Pg.442]    [Pg.156]    [Pg.151]    [Pg.101]    [Pg.101]    [Pg.111]    [Pg.112]    [Pg.77]    [Pg.990]    [Pg.151]    [Pg.207]    [Pg.213]    [Pg.231]    [Pg.189]    [Pg.108]   
See also in sourсe #XX -- [ Pg.29 , Pg.326 ]

See also in sourсe #XX -- [ Pg.10 ]



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