Streptomyces curacoi

From his time at the Squibb research laboratories, he was interested in the chemistry of antibiotics, and in this area, he elucidated the partial structure of curamycin, an antibiotic produced by Streptomyces curacoi. From curamycin, he isolated and characterized the new natural sugar derivatives D-curacose (4-O-methyl-D-fucose), curacin [4-0-(dichlo-roisoeveminyl)-2,6-dideoxy-D-araW/io-hexose], and curamycose (2,6-di-O-methyl-D-mannose). 

Curamycin. Curamycin A is the primary component of the culture Streptomyces curacoi. Curamycin A melts at 192-199°C. 

Curamycin. Curamycin A, presented in Table 2, is the primary component of the culture Streptomyces curacoi (21) and preliminary chemical degradation studies (18) established it to be an oligosaccharide antibiotic. Later when the complete structure was assigned (17,19), the dose rdationship to flambamycin was evident. Curamycin A melts at 192—199°C. 

C59H84CI2O32 1376.199 Oligosaccharide-type antibiotic. Prod, by Streptomyces curacoi. Active against gram-pos. bacteria and some viruses. Cryst. (2-propanol/EtOAc). 

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