Streptomyces clavuligerus clavulanic acid cluster

Li, R., Khaleeli, N. and Townsend, C.A. (2000) Expansion of the clavulanic acid gene cluster identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus. The Journal of Bacteriology, 182, 4087—4095. 

S. clavuligerus produces several antibiotics, including the P-lactams cephamycin C and clavulanic acid, a P-lactamase inhibitor. A SARP type protein, CcaR, is required for the biosynthesis of cephamycin C and clavulanic acid (Perez-Llarena et al. 1997). The clusters of genes for both compounds are located side by side in three different Streptomyces species (Ward and Hodgson 1993) and the ccaR gene is located in the cephamycin gene cluster. 

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