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Streptokinase toxicity

The major toxicity of all thrombolytic agents is hemorrhage. Streptokinase can cause allergic reactions with fever, rash and, although rarely, anaphylaxis. [Pg.374]

HHMM, and HMMM, respectively (Markert, Shaklee, and Whitt 1975). The widespread tissue distribution of LDH differs with the various species (Garbus et al. 1967 Cornish, Barth, and Dodson 1970 Karlsson and Larsson 1971 Schultze et al. 1994). Some additional isoenzymes of LDH have been described, and some LDH isoenzymes may complex with drugs—for example, streptokinase (Podlasek and McPherson 1989). Because LD is a cytoplasmic enzyme, it is increased in serum during hepatocyte or myocyte necrosis and conditions that are toxic to hepatocytes or myocytes. However, it lacks specificity and sensitivity when compared to other enzymes for detection of specific organ injury. In laboratory animals, the primary use for LD has been the detection of experimentally induced myocardial injury (see Chapter 7). [Pg.30]

D. Toxicity Bleeding is the most important hazard and has about the same frequency with all of these drugs. Cerebral hemorrhage is the most serious manifestation. Streptokinase, a bacterial protein, often evokes the production of antibodies and loses its effectiveness or even induces severe allergic reactions upon subsequent therapy. Patients who have had streptococcal infections may have preformed antibodies to the drug. Because they are human proteins, urokinase and t-PA are not subject to this problem. However, they (and anistreplase) are much more expensive than streptokinase and not much more effective. [Pg.309]

No toxic properties have as yet been ascribed to streptokinase, and little is known of the part it plays in the pathogenesis of streptococcal infections. It is probable, however, that the absence of fibrin from exudates associated with streptococcal infections, such as peritonitis or empyema, is due to the presence of streptokinase, since as shown originally by Tillett, when the specific antibody, antistreptokinase, appears in the blood, fibrin appears in such exudates. Presumably streptokinase is inhibited by the antibody. [Pg.133]


See other pages where Streptokinase toxicity is mentioned: [Pg.337]    [Pg.350]    [Pg.374]    [Pg.960]    [Pg.80]    [Pg.265]   
See also in sourсe #XX -- [ Pg.309 ]




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Streptokinase

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