Streptidine 6-phosphate, biosynthesis

The General myo-lnositol and scyllo-Inosamine Pathway. Two distinct cyclitol pathways, which we earlier called Ca (started by myo-inositolphos-phate synthase) and Cb (started by T-deoxy-i cy/to-inosose synthase), are used in the initiation of AGA pathways. Here we will describe the Ca route and the Cb pathway in the paragraph on NEOs (see Section 2.2.2.1.3). The cyclitol pathway in the biosynthetic pathways for STRs, but also for other AGAs such as SPCs, KAS, and FORs and also the mixed type antibiotic HYG-A (see Section 2.2.4.3.1), starts with the formation of myo-inositol in a two-step pathway (Ca) that is not encoded in the itrAtt-clusters. The first step in streptidine biosynthesis (and any other myo-inositol utilising pathway) is the formation of a myo-inositol monophosphate (D-myo-inositol-3-phosphate or L-myo-inositol-1-phosphate) via L-myo-inositol-1-phosphate synthase, which in actinomycetes... 

Bioconversions of aminoglycoside antibiotics have been discussed. Further studies in the biosynthesis of streptomycin have shown that only streptidine-6-phosphate acts as an acceptor for dihydrostreptose in the synthesis of O-a-L-dihydrostreptose(l ->-4)streptidine-6-phosphate using a purified enzyme preparation from S. griseus, and that this pseudodisaccharide could be... 

Kniep B, Grisebach H. Biosynthesis of stieptomycin. Purification and propenies of a dTDP-L dihvdro5treptose streptidine 6-phosphate dihydrostreptosyltransferase from Sirepiomyces griseus. EurJ Biochem 1980 105 139-144. 

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