Toxicokinetics, storage

The toxicity of chemicals to living organisms is determined by the operation of both toxicokinetic and toxicodynamic processes (Chapter 2). The evolution of defense mechanisms depends upon changes in toxicokinetics or toxicodynamics or both, which will reduce toxicity. Thus, at the toxicokinetic level, increased storage or metabolic detoxication will lead to reduced toxicity at the toxicodynamic level, changes in the site of action that reduce affinity with a toxin will lead to reduced toxicity. 

Toxicokinetics Relating to the fate of toxic chemicals within living organisms— that is, questions of uptake, distribution, metabolism, storage, and excretion factors that determine how much of a toxic form reaches the site of action. 

Pharmacokinetics The study of the movement of xenobiotics within an organism. Such a study must consider absorption, distribution biotransformation, storage and excretion. Synonym toxicokinetics. 

Filser, 1993 Kohn Melnick, 1993 Bond et al., 1994 Medinsky et al., 1994 Csanady et al., 1996 Sweeney et al., 1997) predicted, species specifically, similar toxicokinetic behaviour of butadiene. The only exception was the first model of Kohn and Melnick (1993), which contained much higher theoretically derived partition coefficients than the experimentally determined ones, leading to prediction of butadiene storage in fat tissue. In a second, extended version, the authors used average values of the partition coefficients determined experimentally by Johanson and Filser (1993) and Medinsky etal. (1994). 

For compounds of environmental concern, as the mechanisms responsible for uptake, distribution, storage, and elimination from the body are elucidated, more accurate and reliable models will be developed for predicting the toxicokinetic fate of chemicals. 

Toxicokinetics Description of how blood specimens are to be processed and analyzed for test article concentration, including information on the testing laboratory, assay procedure, and storage and shipping procedures... 

Storage of toxicants in tissues can alter both the toxicokinetics and the biologic effects of the toxicant... 

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