Stille nucleotides fluorescent

The design of fluorescent sensors is of major importance because of the high demand in analytical chemistry, clinical biochemistry, medicine, the environment, etc. Numerous chemical and biochemical analytes can be detected by fluorescence methods cations (H+, Li+, Na+, K+, Ca2+, Mg2+, Zn2+, Pb2+, Al3+, Cd2+, etc.), anions (halide ions, citrates, carboxylates, phosphates, ATP, etc.), neutral molecules (sugars, e.g. glucose, etc.) and gases (O2, CO2, NO, etc.). There is already a wide choice of fluorescent molecular sensors for particular applications and many of them are commercially available. However, there is still a need for sensors with improved selectivity and minimum perturbation of the microenvironment to be probed. Moreover, there is the potential for progress in the development of fluorescent sensors for biochemical analytes (amino acids, coenzymes, carbohydrates, nucleosides, nucleotides, etc.). 

Despite the wide applicability of TNP-ATP as a useful fluorescent nucleotide analog, the dynamics of its fluorescence is still not fully understood. To find the origin of change in the apparent fluorescence intensity in different environments, it is important to learn how the local environment influences the fluorescence dynamics. Four important fluorescence characteristics of TNP-ATP are summarized in the following manner [23], First, the fluorescence lifetime of TNP-ATP... 

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