Stereoselective P-Mannosylation on Polymer Support

The Institute of Physical and Chemical Research (RIKEN), Wako-shi, Saitama, Japan 

A drastically distinct use of a polymer support in oligosaccharide synthesis was devised in connection with p-methoxybenzyl (PMB)-assisted intramolecular 

1 p-METHOXYBENZYL-ASSISTED INTRAMOLECULAR AGLYCON DELIVERY HIGHLY EFFICIENT P-MANNOSYLATION 

Seeking for general and highly stereoselective P-mannosylation, our attention was drawn to the approach based on the emerging concept of intramolecular aglycon 

Since all hydroxyl groups of the p-linked mannose residue can be distinguished, stereo- and regiocontrolled synthetic routes to essentially all types of Asn-linked glycans can be conceived. This aspect was demonstrated by the synthesis of 

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