Stepwise Automation of PASP Synthesis in Batch Mode

1 Stepwise Automation of PASP Synthesis in Batch Mode 

The adoption of PASP synthesis presents the opportunity for in-Une purification strategies, through the use of supported scavengers or reagents and catch-and-release strategies. In this way, conventional purification techniques such as aqueous workups and column chromatography can be eliminated. In addition, the use of PASP synthesis reduces the vast number of traditional synthetic manipulations to a series of repetitive incubations and subsequent filtrations, which are in principle well suited to automated processing. 

In this single automated step, 88 reactions were found to have worked. The failures can be largely attributed to the variation in reactivities typically encountered across a given monomer set, and illustrates a recurring problem associated with combinatorial chemistry. 

2 Fully Automated PASP Synthesis of Drug-Like Molecules in Batch Mode 

Recently, a number of publications have dealt with the synthesis of drug-like molecules via fully automated PASP (auto-PASP) synthesis. This scenario entails the use of a series of immobilised reagents and scavenger reagents to perform a variety of sequential synthetic transformations in a common solvent. Each of the transformations 

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