Steps in Chemical Analytical Protocol

The application of statistics to support analytical results is usually the final step in reporting. Statistics can reveal much information about the determined result and ensure confidence in results. It can be applied in several ways and one of its most effective uses is the generation of the control charts to monitor the routine analysis of samples to determine whether the preparation of standards and instrument parameters are correct and no contamination has crept into the sample, reagents and instrument or during sample preparation. A control chart is generated from a control standard and is a visual display of confidence in the method. It can warn the operator if the sample/insfrument parameters are in, or out of, control and whether corrections are necessary before proceeding with the analysis. 

Steps Preparation of liquids Preparation of powder/solids 

1 Sampling Samples must be homogenous and traceable Powder or solid samples must be made representative using subdividing methods. May require more than one sample per bulk material. Liquid samples must be homogenous 

2 Preparation of sample Determination of sample weight/volume for density, etc. Reduction of particles size, drying, test for dissolution in solvents compatible with plasma sources 

3 Dissolution of sample Extent of dissolution to fit calibration range, or limit of detection Complex formation, extraction, wet digestion, dry ashing, fusion, combustion 

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