Stent restenosis stem cells

However, the trial raised important safety questions. Intracoronary infusion of G-CSF-stimulated peripheral-blood stem cells apparently aggravated restenosis after coronary stenting, leading to early termination of the trial. Meanwhile, no temporal association between increased restenosis rate and stenting near the time of intracoronary cell administration has been noted in other studies that have not used G-CSF stimulation. 

Kang HJ, Kim HS, Zhang SY, Park KW, Cho HJ, Koo BK, Kim YJ, Soo Lee D, Soon DW, Han KS, Oh BH, Lee MM, Park YB. Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction the MAGIC cell randomised clinical trial. Lancet 2004 363 751-756. 

Metallic stents covered with stem cells were proposed as a plausible solution for preventing in-stent thrombosis and restenosis. Raina et al. published in 2014 in vivo results of 152 implanted hTEC covered stents and compared the outcomes with BMS. The preliminary results showed earlier strut coverage with endothelial cells and no increased neointimal proliferation compared to BMS [92],... 

Cardiovascular There is a high rate of stent restenosis if intra-coronary infusion of stem cells is carried out within 4 weeks after coronary stenting [100, 101, 102, 103, 104 ]. It should be possible to mitigate this effect by delaying stem cell injection [105 ]. 

Kim KS, Jin J, Lee YY, Choi SI, Shin JH, Kim JH, Lim HG, Lee BH, Choi YY, Lee SM, Koh HC. The timing of intra-coronary infusion of G-CSF mobilized peripheral blood stem cells influences cardiac function and in-stent restenosis in patients with myocardial infarction. Int J Cardiol 2010 143(2) 202-5. 

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