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Stem cell-mediated gene therapy

Moutsatsos, I.K., Turgeman, G., Zhou, S., Kurkalli, B.C., Pelled, G., Tzur, L. et al. (2001) Exogenously regulated stem cell-mediated gene therapy for bone regeneration. Mol. Ther., 3,449 161. [Pg.27]

Bai J, Rossi J, Akkina R (2001) Multivalent anti-CCR ribozymes for stem cell-based HIV type 1 gene therapy. AIDS Res Hum Retroviruses 17 385-399 Bai J, Sui J, Zhu RY, TaUarico AS, Gennari F, Zhang D, Marasco WA (2003) Inhibition of Tat-mediated transactivation and HIV-1 replication by human anti-hCychnTl intrabodies. J Biol Chem 278 1433-1442... [Pg.288]

Aboody KS, Najbauer J, Danks MK (2008) Stem and progenitor cell-mediated tumor selective gene therapy. Gene Ther 15 739-752... [Pg.266]

The trial entailed retroviral-mediated ex vivo transduction of haematopoietic stem cells from 10 young SCID-X1 sufferers, with subsequent re-infusion of the treated cells. A marked and prolonged clinical response in which the condition was essentially reversed was observed in 9 out of the 10 patients. The prolonged response was likely due to the transduction of pluripotent progenitor cells with self-renewal capacity (Chapter 10). However, the two youngest patients (1 and 3 months old at the time of treatment) developed uncontrolled proliferation of mature T-lymphocytes 30 months and 34 months after gene therapy respectively. [Pg.428]

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See also in sourсe #XX -- [ Pg.26 ]



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Gene therapy

Stem Cell Gene Therapy

Stem cell therapy

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