Steady-state plasma concentration Cp ss

The "average" steady-state plasma concentration, (Cp)ss, for an intravenous bolus dose and for an extravascular dose. 

What average steady-state plasma concentration (Cp)ss would be obtained ... 

Table 15.1 Time (to.9) to 90% of steady-state plasma concentration (Cp)ss level as a function of daily dose (R)...

The steady-state trough (minimum effective) plasma concentration obtained after the administration of a maintenance dose is based on the volume of distribution, the fraction of dose remaining (fr = e T), and the fraction of dose eliminated (fei = 1 — e, t) during the dosage interval. Based on a desired trough plasma concentration (Cp ss(min)) at the end of the dosage interval, the maintenance dose that would be required may be calculated as follows ... 

The true steady-state plasma concentration of a drug is constant for a given infusion rate and is obtained as time approaches infinity. We know, by definition, that when t = oo Cp = (Cp)ss- Hence, Eq. 10.3 takes the following form ... 

Plot the difference between the steady-state plasma concentration and the observed plasma concentration in Table 10.4 (i.e. (Cp)ss — (Cp)obs) versus time on semilogarithmic paper (values... 

Cp)obs/ observed plasma concentration (Cp)diff, difference in plasma concentration between steady state and observed, (Cp)ss - (Cp)obs-... 

Determine the infusion rate (Q) of procainamide hydrochloride required to attain the practical and true steady-state procainamide plasma concentrations, (Cp)ss, of 5.7 and 6.0pgmL , respectively. 

If it is desired to attain and then maintain the true steady-state procainamide plasma concentration (Cp)ss of 8mgL in this subject. In answering questions 5-8, make some important observations with regard to parameters that change as a result of change in the infusion rate and parameters that remain unaffected by it. 

Figure 11.4 Plasma concentration (Cp) versus time profile following the administration of an identical intravenous bolus dose of a drug at an identical dosing interval (t). Please note that the steady-etate (ss) peak plasma concentrations are identical. Similarly, the steady-state plasma concentrations at any given time after the administration of a dose are identical, min, minimum max, maximum.

Alternately, if the Michaelis-Menten parameters and the administered dosing rate are known, the steady-state plasma concentration can be predicted. Equation 15.8 may be rearranged to solve for (Cp)ss ... 

Figure 10.10 Predicted or theoretical plasma concentration (Cp) versus time profile following the administration of a drug as an intravenous bolus loading dose (DJ immediately followed by an infusion at rate Q. MTC, minimum toxic concentration MEC, minimum effective concentration ss, steady state.

Figure 10.17 Plasma concentration (Cp) versus time during and post-infusion (rectilinear plot).7, time of cessation of infusion f, time since the infusion was stopped ss, steady state.

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