Starting Points for Kinase Probe Discovery The benefits of chemical connectivity

3 Starting Points for Kinase Probe Discovery The benefits of chemical connectivity 

A number of important lessons can be gleaned from these reports. Importantly, screening sets of diverse kinase inhibitors against a panel of kinases almost always yields hits for every kinase. In the study published by Bamborough et al., at least one hit was found for each of the 203 kinases 

These inhibitors all share the same 2,4-diaminopyrimidine core, yet were made to target different kinases. One can see that the scientists exploring the SAR have incorporated vastly different groups in the 2-, 4-, and 5- positions in order to achieve either potency at the desired target or selectivity over other 

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