Star-shaped polymers peptide blocks

Star-Shaped Polymers with Peptide Blocks... 

Fig. 22 Synthesis of peptide star-shaped polymers by the macromonomer approach Stages are synthesis of PBLG macromonomer with styrene end groups radical polymerization (SERF or RAFT) in the presence of DVB by crosslinking of block copolymers and deprotection of PBLG shell [132]...

An alternative approach to synthesis of star-shaped polymers or nanoparticles is the use of macromonomers. The Heise group prepared PBLG macromonomers with a styrene endgroup by NCA polymerization initiated with 4-vinylbenzylamine. The macromonomers were then copolymerized with divinylbenzene by free-radical or RAFT polymerization (see Fig. 22). Finally, the peptide block was deprotected to give PGA blocks and resulted in pH-responsive water-soluble nanoparticles [132]. 

An arm-first method for the preparation of star-shaped block copolymers and peptide-conjugated polymer nanoparticles was reported by the Heise group. They used nitroxide-functionalized amines for NCA polymerization. The nitroxide... 

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