Stallimycin Hydrochloride

Chemical Name N -(2-Amidinoethyl)-4-formamido-1,1, 1 -trimethyl-N,4 N, 4 -ter-(pyr-role-2 arboxamide) hydrochloride 

A spore suspension obtained upon washing a culture oi Streptomyces distallicus is added to 3,000 ml of a sterile medium consisting of the following  

300 ml of a suspension of the vegetative mycelium of this culture are used for inoculating 6,000 ml of a similar sterile culture medium. At this production stage, the culture is kept fermenting for 85 to 100 hours (pH 7.6 at 2B°C) at a stirring rate of 350 to 450 rpm and a rate of air flow of 1 to 1.5 C/min/(2 of culture medium. 

To 17 C of a culture obtained by submerged fermentation as mentioned above, siliceous earth is added and the batch is filtered. The mixture of mycelium and the siliceous earth are agi-tatedforl hour with 2.5 Cof butanol. This treatment is repeated twice. Thebutanolic extracts are combined, washed with water, evaporated to dry ness (about 10 g) and boiled with acetone (80 ml). The residue (5.41 g of yellowish powder) is distamycin. 

5 g of distamycin is extracted six times with ethanol. The ethanolic extracts are combined, concentrated and filtered through a column containing 70 g of alumina. Elution Is carried 

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Stallimycin [inn] (stallimycin hydrochloride [usan] distamycin A) is a (peptide) ANTIBIOTIC active as an ANTIVIRAL. It is used topically to treat herpes simplex infections. Stallimycin hydrochloride stallimycin. Stanolone [ban] (androstanolone [inn] androstanolone propionate androstanolone enanthate dihydrotestosterone) is a steroid, an androgen and ANABOLIC agent. It has been used orally and topically in the form of an eye ointment. 

Distamycins. Pyrrole antibiotics from Streptomyces distallicus, used topically to treat herpes simplex infections, e.g., D.A (stallimycin) C22H27N,04, Mr 481.51, mp. 154-156 °C used as the hydrochloride... 

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