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Stability of PLGA-Encapsulated Proteins

Department of Pharmaceutical Sciences, The University of Michigan, Ann Arbor, Michigan, U.S.A. [Pg.381]

Formulation Development, Protein Design Labs, Fremont, California, U.S.A. [Pg.381]

Therapeutic proteins have also been stabilized in PLGA millicylinders by neutralizing the acidic microenvironment with insoluble basic additives in combination with additional excipients that improve the intrinsic stability of the encapsulated protein. Two examples are provided below using t-PA and basic fibroblast growth factor. [Pg.406]

Schwendeman, S. P. (2002), Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems, Crit. Rev. Therap. Drug Carrier Syst., 19, 73-98. [Pg.434]

Jiang W, Schwendeman SP. Stabilization of a model formali-nized protein antigen encapsulated in PLGA-based microspheres. J Pharm Sci 2001 90 1558-1569. [Pg.416]

See other pages where Stability of PLGA-Encapsulated Proteins is mentioned: [Pg.409]    [Pg.381]    [Pg.387]    [Pg.391]    [Pg.395]    [Pg.399]    [Pg.401]    [Pg.411]    [Pg.409]    [Pg.381]    [Pg.387]    [Pg.391]    [Pg.395]    [Pg.399]    [Pg.401]    [Pg.411]    [Pg.385]    [Pg.389]    [Pg.43]    [Pg.149]    [Pg.403]    [Pg.405]    [Pg.408]    [Pg.411]    [Pg.413]    [Pg.421]    [Pg.1652]    [Pg.2326]    [Pg.786]    [Pg.12]    [Pg.265]    [Pg.267]    [Pg.386]    [Pg.389]    [Pg.389]    [Pg.393]    [Pg.407]    [Pg.985]    [Pg.332]    [Pg.22]    [Pg.167]    [Pg.449]    [Pg.26]    [Pg.83]    [Pg.399]    [Pg.401]    [Pg.402]    [Pg.411]    [Pg.412]   


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Encapsulating proteins

Encapsulation protein

PLGA

PLGAs

Protein stabilization

Proteins encapsulated

Proteins stabilizers

Stability of Proteins

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