SSRIs psychosis caused

These adverse effects bear some similarity to those of the SSRIs. Although these adverse effects rarely require discontinuation, aggravation of psychosis and seizures caused by this agent do (427, 462, 463 and 464). In contrast to the SSRIs and venlafaxine, bupropion usually does not cause sexual dysfunction. As such, bupropion may be an alternative for patients bothered by these adverse effects (465). Bupropion may also be a useful antidote for SSRI-induced sexual dysfunction (4 53, 455, 466, 467). 

Venlafaxine (Effexor), approved by the FDA in December 1993, was described in more detail early in this chapter. It is one of the newer antidepressants implicated in causing suicidality. It is a NSRI that also strongly inhibits the reuptake of epinephrine. Its profile is very similar to the SSRIs in producing stimulation, including anxiety, nervousness, insomnia, anorexia, and weight loss. It causes the various emotional and behavioral abnormalities that go along with stimulation, such as agitation and mania, and has been associated with hostility, paranoid reaction, psychotic depression, and psychosis. It can cause hypertension. 

Paxil is an SSRI that came out soon after Prozac. In 2001, a Wyoming family was awarded 6.4 million because a Paxil patient murdered his wife, daughter, and granddaughter and then committed suicide. During the trial, the defense lawyers tried to depict the accused as a conscientious and law-abiding man who struggled with depression but loved his family. Somehow Paxil, the family s attorneys argued, caused the man to slip into psychosis. 

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