SREBPs sterol

SREBP sterol regulatory element binding protein... 

Regulation of HMG CoA reductase. SRE = sterol regulatory element SREBP = sterol regulatory elementbinding protein. 

SREBPs Sterol Receptor Element-Binding Proteins... 

In mammals, the liver is the organ most active in lipids synthesis, and in this organelle, the transcription factors SREBPs (sterol-regulatory element binding protein) play crucial roles in lipids homeostasis. In addition to cholesterol,... 

Abbreviations FASN, fatty acid synthase ACC, acetyl-CoA-carboxylase ACL, ATP-citrate lyase NADPH, nicotinamide adenine dinucleotide phosphate MAT, malonyl acetyl transferases KS, ketoacyl synthase KR, p-ketoacyl reductase DH, p-hydroxyacyl dehydratase ER, enoyl reductase TE, thioesterase ACP, acyl carrier protein VLCFA, very long chain fatty acids ELOVL, elongation of very long chain fatty acids SCDl, stearoyl-CoA desaturase-1 AMPK, AMP-activated kinase ME, malic enzyme FASKOL, liver-specific deletion of FAS PPARa, Peroxisome Proliferator-Activating Receptor alpha HMG-CoA, 3-hydroxy-3-methyl-glutaryl-CoA SREBP, sterol response element binding protein SIP, site-one protease S2P, site-two... 

Fig. 6. Coordinated transcriptional regulation of fatty acid desaturases and elongases in mammals. PUFA, polyunsaturated fatty acids +, stimulation inhibition LXR, liver X receptor RXR retinoid X receptor SREBP, sterol regulatory element binding protein ChREBP, carbohydrate response element binding protein Mix, Max-like receptor PPAR-ot, peroxisome proliferator activated receptor alpha LXRE, liver X receptor response element SRE, sterol response element ChoRE, carbohydrate response element PPRE, peroxisome proliferator response element. (See color plate section, plate no. 6.)...

SREBP Sterol regulatory element-binding proteins 1 and 2... 

Several key enzymes in this pathway can be activated through DNA transcriptional regulation of SREBP (sterol regulatory element-binding proteins 1 and 2) [12]. Also, the regulation of this pathway can be achieved by controlling the rate of translation of the mRNA, as well as the level of reductase and kinase (degradation of reductase and phosphorylation). 

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